منابع مشابه
Ticking time bombs: connections between circadian clocks and cancer
Connections between mammalian circadian and cell division cycles have been postulated since the early 20th century, and epidemiological and genetic studies have linked disruption of circadian clock function to increased risk of several types of cancer. In the past decade, it has become clear that circadian clock components influence cell growth and transformation in a cell-autonomous manner. Fu...
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Proteins catalyze crucial reactions via unstable, high-energy chemical intermediates. In the absence of physiological substrates, activated redox cofactors become ticking time bombs, capable of producing oxidative damage to the protein. In PNAS, Gray and Winkler (1) propose that chains of tryptophan (Trp) and tyrosine (Tyr) residues may serve as escape routes for potentially damaging, highly ox...
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Commentary I feel that the brief reports of these eight cases offer their own lessons, but would like to summarize shortly my own opinions. In a case of obstructive jaundice in which there is some doubt as to the cause at laparotomy: i. When the gall bladder is collapsed a careful dissection in the porta hepatis may reveal a growth. UTsually little can be done but f would suggest that by openin...
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To the Editor — Detailed analysis of volcanic materials1 allows the study of eruptions that have not been witnessed directly. Rotella et al.2 undertake the challenge of interpreting submarine volcaniclastic deposits around Macauley Volcano, part of the Kermadec Arc in the southwest Pacific Ocean. They propose a ‘Tangaroan’ eruption style, based on the textural characteristics of dredged pumice ...
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We consider the distribution of economic activity within a country in light of three leading theories – increasing returns, random growth, and locational fundamentals. To do so, we examine the distribution of regional population in Japan from the stone age to the modern era. We also consider the Allied bombing of Japanese cities in WWII as a shock to relative city sizes. Our results support a h...
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ژورنال
عنوان ژورنال: Conjunctions
سال: 2020
ISSN: 2246-3755
DOI: 10.7146/tjcp.v7i1.119862